The study is a prospective, randomised, open label trial, blinded end point outcome assessment22 with balanced randomisation (1:1) conducted in 10 outpatient clinics in Denmark.
Follow-up visits for patients in the intervention group are scheduled to occur at baseline and then after 2, 4 and 12 weeks and thereafter every third month for 5 years after randomisation (see figure 1).
This includes collaborating with stakeholders to understand needs and requirements.At baseline, when the diagnosis of RA is established, blood samples for LDL, DMARD, glycated haemoglobin (Hb A1c) and urine for microalbuminuria will be routinely taken. Kennenlernen greifswald After 2 weeks, patients will be invited to participate in the study if they have LDL2.5 mmol/L and none of the exclusion criteria.Exclusion criteria: Previous disease-modifying antirheumatic drug (DMARD) or oral glucocorticoid treatment, pregnant or lactating women, current infection with parvovirus B19, hepatitis B, hepatitis C or HIV or any condition contraindicating the study medication and a previous report of hospitalisation for myocardial ischaemia defined as follows: (1) non-fatal MI defined according to national and international guidelines, (2) acute coronary syndrome (ACS) including acute ischaemic symptoms with possible biomarker changes or ECG changes that do not meet the criteria for MI, (3) angina pectoris, (4) revascularisation (percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) (Box 1).Other requirements for inclusion are willingness to participate for the duration of the trial.
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The participants in the study have RA diagnosed by the treating rheumatologist.Key inclusion criteria: RA according to the revised American College of Rheumatology (ACR) 2010 criteria27 and plasma low-density lipoprotein (LDL)2.5 mmol/L.We Offer A position that is critical to our success, as you ensure a high level of quality in the way we work, via proper planning through execution and ensuring that we live up to requirements. In this role, you provide functional assurance and support on completion engineering and operational issues across our Danish Business Unit Asset teams.Dissemination will occur through presentations at National and International conferences and publications in international peer-reviewed journals.
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